Investigators
Study information
- Research Area: Maternal and Child health
- Research type: Longitudinal study
- Start date: Jan 01, 2020
- End date: Dec 31, 2022
Study aim of the objectives
General Objective
The overall goal is to quantify changes in the gut microbiome composition and function, and to compare clinical phenotypes by lactational status in healthy mothers and mothers with a high risk of developing CMD (women with a diagnosis of preterm birth, gestational hypertension, preeclampsia, gestational diabetes etc. during pregnancy).
Specific Objectives
1.Quantify changes in gut microbiota, comparing the changes in mothers and their infants who exclusively breastfeed for 4-6 months, against changes in women who do not fully breastfeed at baseline (1st trimester), second trimester, third trimester, and 1, 3, and 6 months postpartum.
2.Correlate the gut microbiome in healthy women and women with adverse pregnancy outcomes who either fully breastfeed or do not fully breastfeed with cardiometabolic health markers (hemoglobin A1c, adiposity, lipid levels, cytokines, C-reactive protein, etc.).
Study setting/Area (Location)
Rwandan Military Hospital (RMH) and Kacyiru District Hospital
Implementing institution
RBC, Rwandan Military Hospital, Kacyiru District Hospital, University of Rwanda, and University of South Florida
Department/Division
Research, Innovation and Data Science
Impact on Policy
It is important to characterize the gut microbiome during lactation to understand bacterial prevalence, as well as functionally active bacteria that could influence the health of the host.